Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (left image, red), a major component of the nuclear lamina. Also shown is th...

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a mutation in the gene for lamin A (red), a major component of the nuclear lamina. Also shown is the distributi...

Shown is a fibroblast from a Hutchinson-Gilford Progeria syndrome patient which carries a truncation in the gene for lamin A (red, left image), a major component of the nuclear lamina. The distributio...

The relationship between the actin cytoskeleton (blue), adherens junctions (green) and phospho-Myosin Light Chain (MLC) (red) after 30 minutes of calcium stimulation.

Localization of the microtubule anchoring factor LL5α (red), microtubules (green), and the microtubule plus-end binding protein, EB1 (blue) in an MCF-10Aeco epithelial cell. EB1 was concentrated in ...

Colocalization of the microtubule anchoring factor LL5α (red) with integrin α6 (blue) in the basal cortex of outer epithelium of mouse mammary gland tissue. LL5 did not colocalize with β-catenin-p...

Colocalization of the microtubule anchoring factor LL5α (red) with integrin α6 (blue) and laminin (green) in the epithelium of mouse small intestine. LL5α is localized to the basal cell cortex atta...

Mouse tracheal epithelia cells (MTEC) were grown at air-liquid interface to induce differentiation, centriole amplification and ciliogenesis. Cells were fixed using ice-cold methanol for 10 min. Sampl...

Colocalization of the microtubule anchoring factor LL5α (red) with integrin α6 (blue) in the basal cortex of outer epithelium of mouse mammary gland tissue, and laminin (green) in the basement membr...

Behavior of a patient-derived human fibroblast line (PD-NC4) containing a mutated chromosome 4 in which the normal centromere is epigenetically silenced and a neo-centromere has formed 25 Mbp down the...